Insomnia affects all of us from time to time. Consistent sleeplessness often results in a prescription for sleeping pills, which can have unfortunate side effects. Cannabis is a natural way to treat those restless nights – as long as you’re using the right strain. Learn about the best strains for insomnia and why cannabis is the go-to solution for so many!

How Does Cannabis Affect Sleep?

Studies into how cannabis affects sleep are lacking due to restrictions placed on using marijuana for medical research. However, the research that does exist suggests that the endocannabinoid system within our body – the system that THC, CBD, and other cannabinoids interact with – plays an important role in sleep regulation. Because cannabis successfully interacts with the endocannabinoid system, it’s fair to utilize the plant as a solution to sleeping issues.   

Furthermore, additional research has found that cannabis increases Stage 3 sleep and reduces the amount of REM sleep we experience. REM sleep is the light sleep in which we dream, while Stage 3 sleep is the deeper sleep thought to be the most important for those suffering from a sleep deprivation condition.

Indica, Sativa, or Hybrid?

Not all strains of cannabis are created equal, as far as treating one’s symptoms. Indica tends to treat insomnia most effectively due to the strong, physical body high it produces, as well as its less psychoactive effects. Sativa often has the opposite effect with its energetic, uplifting “head” buzz. High-THC strains can also have adverse effects on falling asleep, so finding one with a balance of THC and CBD is ideal.

That being said, there are many hybrid strains ideal for treating insomnia, as well. Below we have compiled some of our favorites.   

8 of the Best Strains for Insomnia

Grandaddy Purple

Grandaddy Purple is a classic indica strain that smells and tastes of grapes. It produces a powerful cerebral high combined with the sedating effects of a pure indica, and is a favorite among patients whose pain keeps them up at night.  


Bubba Kush

Bubba Kush is a well-balanced indica that is not too high in THC, making it an ideal choice for those who lack sleep. It offers relaxation and ease, not to mention the sweet flavors of rich chocolate and coffee.

Girl Scout Cookies

The beloved Girl Scout Cookies hybrid strain offers knockout sedative effects while also treating pain, anxiety, and other conditions that keep you up at night. Try it as an edible to guarantee a peaceful, all-night slumber.  

Tahoe OG Kush

Tahoe OG Kush is a top nighttime hybrid, as it provides an extremely lazy, heavy body sensation. Due to superb breeding, Tahoe OG embodies all of the typical indica effects with an added euphoric, sativa-like kick.


God’s Gift

This indica is not for the cannabis beginner. It produces a heavy body high that instills a deep sense of peace and relaxation. With the lingering smell and taste of berries, you’ll find yourself floating away into sleep.  

Sweet Cooks

A Medithrive special, this hybrid of OG Kush and Platinum Girl Scout Cookies offers the ideal balance of sedation and euphoria to help you drift off to sleep feeling happy and relaxed.

Khalifa Kush

Khalifa Kush, or Wiz Khalifa OG, is a hybrid that was bred specifically for the rap artist Wiz Khalifa, who claims it descended from an OG strain. The effects and aromas are similar to that of OG Kush: sour lemon and pine, with an active cerebral buzz that can nevertheless aid in a restful night’s sleep.



Although Skywalker is higher in THC than many strains on this list, this indica is known for helping with insomnia due to its ability to quell anxiety, feelings of stress, and pain. Start with a small dose of Skywalker before bed and feel your tension slip away.

Stop by Medithrive today for these best strains for insomnia! Our budtenders are knowledgeable and compassionate, and will help you find the right strain for your sleepless symptoms. You can also order online – we deliver from 12-8 p.m. seven days a week, and delivery is always free on Tuesdays!